Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Although this guidance reflects the current scientific Background Information. Isocyanates and thioisocyanates, such as 2,4,4-TRIMETHYLHEXAMETHYLENE DIISOCYANATE, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. The acute toxicity of hexamethylene diisocyanate after oral intake is moderate with LD 50 values of > 710 mg/ kg body weight and ≥ 350 mg/kg body weight in rats and mice, respectively (Table 2). HDI is a colorless liquid with an irritating odor. HDI is the common name for hexamethylene diisocyanate. 1969; Union Carbide 1964). Chronic Toxicity (or Exposure)

Specific target organ toxicity (single exposure) Category 3 Hexamethylene diisocyanate (HDI) is the organic compound with the formula (CH 2) 6 (NCO) 2.It is classified as an diisocyanate.It is a colorless liquid. Uses advised against Food, drug, pesticide or biocidal product use.
After dermal exposure, the LD 50 in the rabbit is ≥ 570 mg/kg body weight (NIOSH 1978; Smyth et al. 1.1 WHAT IS HEXAMETHYLENE DIISOCYANATE? The discussion focuses on two widely used diisocyanate-based products: diphenylmethane diisocyanate (MDI) and toluene diisocyanate (TDI) (2)(3)(4). health effects from diisocyanate (1) exposure, and to provide guidance to assist with medical diagnosis and management. uene diisocyanate (TDI), diphenylmethane diisocya- nate (MDI), hexamethylene diisocyanate (HDI), and isophorone diisocyanate (IPDI), are used extensively in the production of polyurethane compounds, which From “the Department of Chest Medicine, Sac&Coeur Hospital. This article addresses results of two 13-wk inhalation toxicity studies in Wistar rats with aerosolized 1,6-hexamethylene diisocyanate (HDI) homopolymers using either the isocyanurate (HDI-IC) type or biuret (HDI-BT) type. With most isocyanates, with the exception of MIC, direct effects ensue a few hours after exposure. HDI is found in hardening agents for automobile paints. Hexamethylene diisocyanate (HDI) is used in the preparation of dental materials, medical adsorbents, and contact lenses, and is used as a polymerizing agent in polyurethane paints and coatings. It is also known as 1,6-hexamethylene diisocyanate, 1,6-diisocyanatohexane, Mondur HX, and Desmodur H. It is a pale yellow liquid with a strong odor. Diisocyanate toxicity may range from temporary reversible to long-term irreversible damage (Axford et al., 1976) as well as delayed appearance of complications (Le Quesne et al., 1976). Synonyms Hexamethylene diisocyanate Recommended Use Laboratory chemicals.